Can I start Ekeler and Jackson this week?

So I handcuffed Ekeler with Jackson and drafted Bell. With Bell on his bye and the Chargers playing Miami, is it crazy to start 2 RBs from the same team? (Sidenote: I also have Keenan Allen)

Other RB options on my team are James White, Tarik Cohen, Tony Pollard, Darrell Williams. I feel Jackson has as good a shot as any of those other guys to score 15+.

Full PPR; rest of roster:

QB: Kyler Murray
WR: Michael Thomas
WR: Keenan Allen
RB: Ekeler
RB: ???
TE: Andrews
Flex: Godwin

I’ve got big play ability from KA, Ekeler, and Godwin so I think I want the safest option at RB2.