Concern for Chargers in London?

It occurs to me that the London game kicks off at 6:30 PST. There’s always a concern about west coast teams travelling east for an early game, and this is a west coast team travelling really far east for a very early game.

Should this concern factor into expectations for Chargers players? For example, should I tilt away from picking up the Chargers DEF and instead go after Washington or Indy?

I would be taking Indy against the Bills regardless of whether or not chargers players are tired. Indy has been low key one of the better performing fantasy defenses in the game. A lot of sacks by that team and with buff starting nathan peterman, I’m always happy to stream a D against that.