Don’t overthink pick 1. That group of 'Quon, CMC, and Kamara are all studs. Nobody would blame you for taking any of them first overall.
Do a lot of mocks and get a feel for the group of guys that are coming around to your end of the board in those crucial rounds, 2 thru 8.
You’ll want to know whether you’re snagging a QB or TE early, or waiting at those positions.
You’ll also want to figure out where the sweet spots are for picking up those super important 2nd and 3rd RBs and WRs.
You’ll also have to come to terms with the fact that you may have to reach if one of your guys keeps winding up at the other end of the board.
Don’t over-determine things, though. Be flexible. Always have a group of guys – not just two – at each turn that you would be happy with. This way, you’re not devastated when someone comes off the board.
You wouldn’t believe the number of drafts I’ve participated in where coaches need 5 minutes to reassess their entire world view just because the guy in front of them took the player they had their hopes set on (MIND BLOWN!). It’s hilarious.
As Andy, Jason, and Mike say: BE WATER.