Mixon vs Seattle
or
Ekeler vs Ind?
I would go Mixon, but it would also help to know who your other running backs are, if this is a flex spot, is your team loaded at wr so you just need a safer player or boom player at rb?
My RBs are Aaron Jones, Sony Michel Alexander Mattinson and the two that I mentioned. WRs are Julio Jones Mike Williams Cooper Kupp and Geronimo Allison