Thursday Night Conundrum

PPR. I have Murray, Howard, and Drake as my available RBs; Drake and Howard are in my two RB slots. I have two FLEX spots dedicated to Boyd and Kupp. Do I play Drake in the RB spot for this Thursday in anticipation that Kupp will be out and put Murray in the FLEX? Or do I put Murray in the RB slot and gamble that Kupp will play and maybe have to sub in Djax or Buck Allen?

MCL sprain. I would not be gambling on Kupp playing this week.