Trade Up in Dynasty Draft?

I currently have a plethora of picks this year due to some good deals last year.

I am holding picks 1.5/1.7/1.9/2.2/2.6.

Should I try and package some to move up for some sure fire players? Especially the 2nd rounders? I am solid at RB (hopefully) with Akers, Mixon, CEH, Gibson as my main dudes plus Bell and Henderson. My WR and QB struggles are real though.
I have Kupp and Chark as my top two then it drops off significantly to Hardman, M Williams, DPJ, Cam Sims, and Harry.
QBs are Hurts, Big Ben, Darnold, and Winston