When to target QB's in a 2 QB auction draft

I’m in my buddy’s 2 QB full PPR auction league/draft and was wondering when you guys thought I should target the QB’s. Should my first nomination be a QB? I’d like to get at a minimum 2 mid tier QB’s and a low tier bench QB (starter, not a backup on his team). I’ve read articles saying to nominate people you don’t want, but the articles were always written for 1 QB auction leagues. Any advice would be greatly appreciated!

I’m in a similar situation. 2-QB auction except 6-PT TD. I’d like to understand how much budget I should spend on the QB position…maybe as high as 40%. That position is going to dominate the points and streaming will be brutal.